1,4-Pentadien-3-one derivatives derived from curcumin possess excellent inhibitory activity\nagainst plant viruses. On the basis of this finding, a series of novel 1,4-pentadien-3-one derivatives\ncontaining a 1,3,4-thiadiazole moiety were designed and synthesized, and their structures confirmed\nby IR, 1H-NMR, and 13C-NMR spectroscopy and elemental analysis. The antiviral activities of\nthe title compounds were evaluated against tobacco mosaic virus (TMV) and cucumber mosaic\nvirus (CMV) in vivo. The assay results showed that most of compounds had remarkable antiviral\nactivities against TMV and CMV, among which compounds 4b, 4h, 4i, 4k, 4o, and 4q exhibited good\ncurative, protection, and inactivation activity against TMV. Compounds 4h, 4i, 4k, 4l, 4o, and 4q\nexhibited excellent protection activity against TMV, with EC50 values of 105.01, 254.77, 135.38, 297.40,\n248.18, and 129.87 �¼g/mL, respectively, which were superior to that of ribavirin (457.25 �¼g/mL).\nIn addition, preliminary SARs indicated that small electron-withdrawing groups on the aromatic\nring were favorable for anti-TMV activity. This finding suggests that 1,4-pentadien-3-one derivatives\ncontaining a 1,3,4-thiadiazole moiety may be considered as potential lead structures for discovering\nnew antiviral agents.
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